Frontiers

Advances in interleukin-10-based therapies for pulmonary diseases: focus on targeted lung delivery systems

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that exerts diverse effects on immune regulation. It alleviates excessive inflammatory responses in the body by inhibiting the expression of pro ...
eLife

The Geometry and Dimensionality of Brain-wide Activity

This important study shows a surprising scale-invariance of the covariance spectrum of large-scale recordings in the zebrafish brain in vivo. A convincing analysis demonstrates that a Euclidean random ...
C&EN

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity

Bristol Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States ...
Frontiers

Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications

This review aimed to elucidate the mechanisms through which (i) physical activity (PA) enhances neuroplasticity and cognitive function in neurodegenerative disorders, and (ii) identify specific PA ...
C&EN

Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2)

The following conditions were used: pH 8.0, 20 mM Tris–HCl, 1 M sodium citrate at 37 °C, and KLK2 molar concentration = 1.6 nM. The kinetic parameters were obtained by running three enzymatic ...