Until now, the exact configuration of the replisome, a protein complex that unzips and copies DNA, has been unknown. After taking the first pictures of this complex, researchers were surprised to find ...

DNA-binding proteins are proteins that bind to single- or double-stranded DNA, generally in the major groove if the binding is sequence-specific – as with transcription factors that regulate ...

Telomeres must overcome specific challenges to ensure their efficient replication. In yeast cells, telomeres are replicated in late S phase in agreement with the late firing of subtelomeric origins.

A, Schematic representation of DPY30 interactors involved in DNA repair, replisome, and proteosome signaling pathways in PATC53, PATC66, and KPC cells. B, Co-IP analysis of HA in 293T cells ...