In rolling circle replication, the newly formed leading strand becomes the template for lagging-strand synthesis, producing a duplex 'tail' composed of the newly synthesized leading and lagging ...

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome—a block of proteins responsible for unwinding the DNA ...

Accurate DNA replication is essential for genome maintenance. Two recent reports have uncovered new molecular mechanisms controlling the termination phase of DNA replication in higher eukaryotes and ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

These cartoons show the old "textbook" view of the replisome, left, and the new view, right, revealed by electron micrograph images in the current study. Prior to this study, scientists believed the ...

It may be time to update biology texts to reflect newly published data from a collaborative team of scientists at Rockefeller University, Stony Brook University, and the U.S. Department of Energy’s ...

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome--a block of proteins responsible for unwinding the DNA ...

Until now, the exact configuration of the replisome, a protein complex that unzips and copies DNA, has been unknown. After taking the first pictures of this complex, researchers were surprised to find ...