The B cell transmembrane glycoprotein modulates immune signaling. Mice containing specific Cd22 mutations show that the extracellular glycan-binding function is regulatory and indicate unexpected ...

Siglecs are sialic-acid-binding immunoglobulin-like lectins that are mostly expressed by cells of the immune system. Siglecs can be divided into two subsets based on their sequence similarity and ...

Researchers have found that restoration of B cell function in BCR signaling deficiencies involves the interaction of CD22, normally an inhibitory factor, with binding partners on the same cell, which ...

In many neurodegenerative disorders, microglia come down with a kind of indigestion, and no longer degrade lipids and other molecules. In the December 1 Science Translational Medicine, researchers led ...

When antigens interact with the antigen receptor on B cells, B cells undergo activation and differentiation to antibody-producing cells (plasma cells). Defects in signaling through the antigen ...

Hairy-cell leukemia that is resistant to treatment with purine analogues, including cladribine, has a poor prognosis. We tested the safety and efficacy of an immunotoxin directed against a surface ...

In the central nervous system, microglia are responsible for scouting around for debris such as damaged neurons and protein plaques, and then cleaning it up in a process known as phagocytosis. As the ...

Researchers from TMDU find that CD22 restores B cell function in B cell receptor (BCR) signaling deficiencies by interacting with cis-ligands and upregulating BCR expression, thereby paradoxically ...